There has been growing interest in the use of cannabis-based products for the treatment of a wide range of diseases, including epilepsy. A number of studies were published during the last 5 years

demonstrating efficacy of purified CBD for the control of a large spectrum of seizure-types, particularly those observed in severe childhood epilepsies, such as Lennox- Gastaut and Dravet syndromes. This book, co-authored by leaders in the field of epileptology, critically reviews recent data from clinical trials. Authors discuss issues related to pharmacology, drug interactions, efficacy, potential adverse events and

long-term effects on development and behaviour. Child and adult neurologists and all clinicians contributing to epilepsy care will find useful information on the best practices, when using purified CBD for the treatment of

drug-resistant epilepsies.

Epileptic Disorders

In 1997, Jean AICARDI, one of the most brilliant child neurologists of our era, commented on "How the view has changed" in the field of pediatric epilepsy surgery : "Surgery for epilepsy has now become a realistic therapeutic option for selected children and the field is likely to increase in the near future. It is now realised that procrastination, in the hope that new antiepileptic drugs will become efficacious, is not justified for some forms of epilepsy that can often be recognised from onset or after a relatively short course. It is also becoming clear that surgery is not reserved for a highly selected population of patients with normal intelligence and focal seizures, but may also help a proportion of more severe epilepsies if a realistic view of the problem and perspectives is taken by the partners". Twenty years later, the most obvious and probably still the strongest reasons against epilepsy surgery in children are cultural and psychological. This book, written by members of the ad hoc ILAE Task Force for pediatric epilepsy surgery and experts in the field, is the result of continued collaborative working between pediatric epilepsy surgery centres over the years. Authors critically review all available data and set out the key elements of presurgical evaluation, the specific electro-clinical presentations per etiology, the range of outcomes to be monitored, and the surgical techniques used today. What becomes obvious when reviewing all available data is that the key to optimized outcome in children with epilepsy is early appropriate recognition of possible surgical candidates and timely referral to centres with expertise.

Pediatric Epilepsy Surgery

The aim of this book is to take a critical look at what is known about outcome of childhood epilepsies, specifically evidence based findings, and further clarify the direction of clinical and fundamental research for the future.  At the time a diagnosis of epilepsy is made for a child, it is highly desirable to predict seizure control and social outcome several months or even years later.  Determination of outcome is, however, complex and in order to confront this challenge, a number of simple questions should be addressed:  What is to be predicted? This may be seizure control, remission with or without ongoing AED treatment, intractability, social outcome, quality of life, or a combination of the above. What is the purpose of attempting to predict outcome and who will use the information? How accurate is the prediction?

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